Tudca

Liver Support 250 mg of tauroursodeoxycholic acid (TUDCA) and 75 mg of additional choline to optimally support liver health, microbiome balance, metabolism, and neurological health. 250 mg of TUDCA per capsule to optimally support liver health, microbiome balance, metabolism, and neurological health. TUDCA is a conjugated bile salt that is important for bile synthesis and reducing fat accumulation in the liver. It also reduces endoplasmic reticulum stress, thereby supporting cellular function in nervous tissue and other organ systems. 75 mg of choline per capsule, as a highly bioavailable choline bitartrate salt, provides a relatively high amount of elemental choline to support neurological function, cognition, and liver health through the production of phosphatidylcholine, bile, acetylcholine, and betaine. Bile salts are one of the main components of bile, a fluid essential for digesting fats, absorbing fat-soluble vitamins, eliminating waste, and forming hormones. Bile and bile salts are produced by the liver and stored in the gallbladder between meals. A bile salt deficiency can cause poorly digested fats to pass through the digestive tract, causing flatulence, cramps, loose stools, and, ultimately, an increased risk of gallstone formation. Tauroursodeoxycholic acid, more commonly known as TUDCA, is a conjugated bile salt that may contribute to gallbladder and liver health. Specifically, TUDCA has been shown to be a safe and effective support for patients with primary biliary cholangitis (PBC), a chronic autoimmune disease that causes bile to build up in the liver, and it may protect the liver from damage caused by liver cirrhosis due to long-term alcohol consumption. TUDCA has also been shown to slow the progression of metabolic dysfunction-associated fatty liver disease (MASLD) in mice fed a high-fat diet by reducing intestinal inflammation, improving intestinal barrier function, decreasing intestinal fat transport, and modulating the composition of the gut microbiota. Another study in mice also showed that TUDCA could potentially hinder the development of gallstones by reducing fat absorption in the intestinal tract. Although TUDCA's role in liver and gallbladder health may seem more obvious, TUDCA also has a unique mechanism of action beyond biliary support. TUDCA has been shown to relieve endoplasmic reticulum (ER) stress in cells, thereby improving protein folding and cell signaling. TUDCA's ability to reduce ER stress extends its potential health benefits beyond liver health to a wide variety of chronic diseases that have demonstrated ER stress. Mechanistically, TUDCA also provides cellular protection by better regulating apoptosis. One of the most important applications of TUDCA's cellular protective role is in the field of neurological health. Animal studies have shown that TUDCA serves as a neuroprotectant against acute injuries such as stroke, as well as chronic neurodegenerative diseases. TUDCA also shows promise in reversing metabolic disorders caused by excess body fat and malnutrition. Indeed, TUDCA has been found to significantly improve insulin sensitivity in liver and muscle tissue. In a study of aged mice, TUDCA reduced hyperinsulinemia and improved glucose regulation by enhancing the liver's ability to break down insulin. Finally, TUDCA has also demonstrated protection against cell death in retinitis pigmentosa and defense against renal fibrosis, and even cardioprotective function by reducing scar tissue, cell death, and cardiac damage in mouse hearts subjected to increased stress. TUDCA by CytoMatrix combines 250 mg of tauroursodeoxycholic acid (TUDCA) with 75 mg of supplemental choline to optimally support liver health, microbiome balance, metabolism, and neurological health. Choline, like TUDCA, is also essential for the manufacture of bile and the liver's elimination of cholesterol. TUDCA by CytoMatrixprovides choline in the form of VitaCholine®, a patented and clinically studied choline bitartrate salt. VitaCholine® offers a relatively high amount of elemental choline, which dissolves quickly and becomes available in the body as free choline, without the need for enzymatic release. VitaCholine® also supports neurological function, cognition, and liver health through the production of phosphatidylcholine, bile, acetylcholine, and betaine.