Various plant extracts can support the use of melatonin and also support sleep parameters. One of the best-studied herbs for insomnia is Valeriana officianalis, commonly known as valerian root. In vitro data have shown that valerian root can stimulate the release of gamma-aminobutyric acid (GABA) in the brain and simultaneously block its reuptake. This may explain why valerian root showed comparable efficacy to a benzodiazepine medication for sleep quality after a 4-week intervention, but with fewer side effects. A meta-analysis examined 16 studies of valerian root on sleep quality, finding a relative improvement in sleep markers of 80% compared to placebo in a subset of trials. Passiflora incarnata and Melissa officinalis are two other calming herbs that stimulate GABA receptors and positively regulate stress, respectively. Studies examining Passiflora incarnata have shown that even just 7 days of consumption in tea form can improve sleep parameters, and its supplementation can significantly reduce stress. Finally, Scutellaria lateriflorais is included for its nervine effects and activation of GABA receptors, primarily due to the active ingredient baicalin. In addition to melatonin and plant extracts, amino acids may play a positive role in alleviating insomnia. GABA is a well-known inhibitory neurotransmitter that has been found to relax the mind and reduce the time it takes to fall asleep. Similarly, L-theanine is a unique amino acid, naturally present in green tea, which is well known for calming the mind and improving concentration. Research has shown that L-theanine can increase levels of various neurotransmitters in the brain, such as serotonin, dopamine, and GABA, while blocking excitatory glutamate receptors. Ultimately, L-theanine increases alpha brain waves and improves stress markers such as heart rate, blood pressure, and salivary immunoglobulin A. Each of these aforementioned ingredients is included in Sleep-Matrix Melatonin to address several possible causes of poor sleep in people with insomnia. Sleep-Matrix Melatonin is an evidence-based blend indicated for increasing sleep latency, duration, and quality. 60 vegetarian capsules per bottle.
Adults: Take 1 to 2 capsules daily or as directed by a healthcare professional. Take a single dose 30 to 60 minutes at or before bedtime. Take a dose earlier in the evening if needed. For jet lag: Take once daily at bedtime, during travel, and at your destination until adjusted to the new time zone/or daily routine.
Ingredients (per capsule): Melatonin (N-acetyl-5-methoxytryptamine) 2 mg, Lemon Balm Extract (higher plant, Melissa officinalis) 5% Rosmarinic Acid 125 mg, L-Theanine 100 mg, Valerian Extract (root, Valeriana officinalis) 0.8% Valerenic Acid 56 mg, Passionflower Extract (higher plant, Passiflora incarnata) 10:1, DHE 500 mg, Skullcap Extract (higher herb, Scutellaria lateriflora) 50 mg, GABA (4-aminobutyric acid) 50 mg Non-medicinal ingredients: Microcrystalline cellulose, magnesium stearate, maltodextrin. Capsule: hypromellose.