Designed to reduce inflammation and intestinal permeability in the digestive tract.
L-glutamine acts as the primary fuel for enterocytes and helps restore tight junctions in the digestive tract lining.
Zinc carnosine provides anti-Helicobacter pylori and gastroprotective properties.
N-acetylglucosamine is included for its ability to support the mucin layer of the intestinal tract.
Bacillus coagulans IS-2, a spore-forming bacterium, is added for its ability to treat IBS and functional abdominal pain in children, as well as IBS and constipation in adults.
The lining of the digestive tract is selectively permeable. It allows for the absorption of nutrients while simultaneously providing a protective barrier to the outside world. In cases of disease or inflammation, the intestine may experience increased intestinal permeability. This is commonly referred to as leaky gut. Increased intestinal permeability has been linked to certain medications, food allergies, infections, various intestinal diseases, and irritable bowel syndrome. While eliminating offending environmental and external factors is an essential part of care, specific nutrients have been shown to help repair intercellular tight junctions and restore optimal permeability.
L-glutamine is one of the most well-known and crucial amino acids for human health. Not only is it necessary for the production of glutathione, but it is also considered a primary fuel for macrophages and lymphocytes necessary for good immunity, as well as for the enterocytes that line the digestive tract. L-glutamine appears to be most needed during periods of convalescence, as muscle glutamine levels drop significantly due to significant stress.
For example, improved digestive health has been observed with glutamine supplementation under various stressors. Decreased diarrhea and fewer digestive upsets have been reported in supplemented individuals with digestive disorders and those taking antiviral medications. These digestive benefits are thought to be due to its role in restoring tight junctions and reducing intestinal permeability.
Zinc carnosine (ZnC), a combination of elemental zinc and the amino acids beta-alanine and histidine, is another nutrient being extensively researched for its gastroprotective abilities. ZnC helps restore glutathione levels in damaged gastric mucosa and also inhibit the production of pro-inflammatory cytokines. One study found that co-administration of ZnC with indomethacin decreased subsequent intestinal permeability associated with NSAID use. Another study demonstrated that up to 72% of subjects with gastric tissue damage achieved remarkable improvement after 4 to 8 weeks of ZnC treatment. Finally, ZnC has potent antimicrobial actions against Helicobacter pylori. For example, the addition of ZnC to "triple therapy," the traditional pharmaceutical treatment for H. pylori eradication, is more effective than when compared to triple therapy alone. N-acetylglucosamine (NAG) plays an important role in supporting a specific part of the intestinal tract lining known as the mucin layer. In a healthy gastrointestinal tract, mucin acts as a barrier between the microbiome and the epithelial wall. However, this barrier is thinner or breaks down in pathological conditions, allowing bacterial penetration and inflammation. Glucosamine is necessary to rebuild mucin, and NAG has been shown to be preferentially incorporated into the intestinal mucin layer compared to other glucosamine sources such as glucosamine sulfate. More importantly, NAG improves mucin thickness and clinical symptoms. Finally, as part of the gastrointestinal tract mucosal healing process, probiotics are worth mentioning. Spore-forming probiotics such as Bacillus coagulans are renowned for their ability to survive even the harshest environments. In fact, spores of Bacillus strains can survive in a dormant state for years, despite extreme temperature changes and pH shifts. Spore germination and activation take place in the small intestine, where sugars, amino acids, and purines are widely available.
Once germinated and activated, Bacillus coagulans can promote digestion, increase nutrient absorption, and reduce inflammation by producing a variety of enzymes and short-chain fatty acids. In addition, Bacillus coagulans exerts a natural antimicrobial effect by competing for resources and inhibiting the growth of pathogenic bacteria. It does this by creating an anaerobic and acidic environment in the intestine, making it inhospitable to various pathogens and providing ideal conditions for the proliferation of beneficial bacteria, such as Lactobacillus and Bifidobacterium species.
Overall, Bacillus coagulans helps promote a favorable intestinal flora by improving the diversity, composition, and metabolic function of the microbiota. Clinical studies have shown that Bacillus coagulans strain IS-2 is effective in treating irritable bowel syndrome (IBS) and functional abdominal pain in adults, as well as IBS and constipation in children. GI Matrix contains a blend of L-glutamine, zinc carnosine, n-acetylglucosamine, and Bacillus coagulans, designed to reduce inflammation and intestinal permeability in the digestive tract. Each of these nutrients is delivered in clinically validated dosages to promote bowel regularity, manage symptoms of irritable bowel syndrome, and promote a healthy gut flora. GI Matrix is unflavored, easily soluble, and lightly sweetened with monk fruit extract to improve compliance. The box contains 60 servings, providing a 30-day supply of the full daily dose.
L-glutamine is one of the most well-known and crucial amino acids for human health. Not only is it necessary for the production of glutathione, but it is also considered a primary fuel for macrophages and lymphocytes necessary for good immunity, as well as for the enterocytes that line the digestive tract. L-glutamine appears to be most needed during periods of convalescence, as muscle glutamine levels drop significantly due to significant stress.
For example, improved digestive health has been observed with glutamine supplementation under various stressors. Decreased diarrhea and fewer digestive upsets have been reported in supplemented individuals with digestive disorders and those taking antiviral medications. These digestive benefits are thought to be due to its role in restoring tight junctions and reducing intestinal permeability.
Zinc carnosine (ZnC), a combination of elemental zinc and the amino acids beta-alanine and histidine, is another nutrient being extensively researched for its gastroprotective abilities. ZnC helps restore glutathione levels in damaged gastric mucosa and also inhibit the production of pro-inflammatory cytokines. One study found that co-administration of ZnC with indomethacin decreased subsequent intestinal permeability associated with NSAID use. Another study demonstrated that up to 72% of subjects with gastric tissue damage achieved remarkable improvement after 4 to 8 weeks of ZnC treatment. Finally, ZnC has potent antimicrobial actions against Helicobacter pylori. For example, the addition of ZnC to "triple therapy," the traditional pharmaceutical treatment for H. pylori eradication, is more effective than when compared to triple therapy alone. N-acetylglucosamine (NAG) plays an important role in supporting a specific part of the intestinal tract lining known as the mucin layer. In a healthy gastrointestinal tract, mucin acts as a barrier between the microbiome and the epithelial wall. However, this barrier is thinner or breaks down in pathological conditions, allowing bacterial penetration and inflammation. Glucosamine is necessary to rebuild mucin, and NAG has been shown to be preferentially incorporated into the intestinal mucin layer compared to other glucosamine sources such as glucosamine sulfate. More importantly, NAG improves mucin thickness and clinical symptoms. Finally, as part of the gastrointestinal tract mucosal healing process, probiotics are worth mentioning. Spore-forming probiotics such as Bacillus coagulans are renowned for their ability to survive even the harshest environments. In fact, spores of Bacillus strains can survive in a dormant state for years, despite extreme temperature changes and pH shifts. Spore germination and activation take place in the small intestine, where sugars, amino acids, and purines are widely available.
Once germinated and activated, Bacillus coagulans can promote digestion, increase nutrient absorption, and reduce inflammation by producing a variety of enzymes and short-chain fatty acids. In addition, Bacillus coagulans exerts a natural antimicrobial effect by competing for resources and inhibiting the growth of pathogenic bacteria. It does this by creating an anaerobic and acidic environment in the intestine, making it inhospitable to various pathogens and providing ideal conditions for the proliferation of beneficial bacteria, such as Lactobacillus and Bifidobacterium species.
Overall, Bacillus coagulans helps promote a favorable intestinal flora by improving the diversity, composition, and metabolic function of the microbiota. Clinical studies have shown that Bacillus coagulans strain IS-2 is effective in treating irritable bowel syndrome (IBS) and functional abdominal pain in adults, as well as IBS and constipation in children. GI Matrix contains a blend of L-glutamine, zinc carnosine, n-acetylglucosamine, and Bacillus coagulans, designed to reduce inflammation and intestinal permeability in the digestive tract. Each of these nutrients is delivered in clinically validated dosages to promote bowel regularity, manage symptoms of irritable bowel syndrome, and promote a healthy gut flora. GI Matrix is unflavored, easily soluble, and lightly sweetened with monk fruit extract to improve compliance. The box contains 60 servings, providing a 30-day supply of the full daily dose.
Adults: Take 1 scoop, 2 times daily with food or as directed by a healthcare professional. Take at least 2 to 3 hours before or after taking antibiotics, other medications, or natural health products.
Ingredients (per scoop): Bacillus coagulans IS-2 1 billion UFCL, glutamine 4.5g, N-acetylglucosamine 500mg, zinc L-carnosine 37.5mg Non-medicinal ingredients: Monk fruit extract, maltodextrin