SAMe (S-Adenosylmethionine)

SAMe with enhanced stability to promote healthy mood balance and comfort for osteoarthritic joints SAMe (S-Adenosylmethionine) is a metabolite found in all living cells. It is a methyl group donor in over 100 different reactions and contributes to the synthesis, activation, and/or metabolism of hormones, neurotransmitters, nucleic acids, phospholipids, and proteins. Methyl groups act as a signal in the body, regulating gene expression and cellular function. As demonstrated in over 40 clinical studies, SAMe also promotes mood balance. In a meta-analysis pooling results from 25 controlled clinical trials involving 791 subjects, SAMe had a statistically significant positive effect on mood, likely due to its support for the synthesis and activity of monoamine (a neurotransmitter), including dopamine and serotonin. It also promotes healthy protein turnover and maintains healthy phospholipid methylation to support phosphatidylcholine production and the integrity and fluidity of cell membranes. Studies suggest that it also supports joint comfort and flexibility in people with osteoarthritis. In a meta-analysis pooling results from 11 studies, SAMe demonstrated statistically significant support for joint function. It is believed to relieve osteoarthritis pain by supporting proteoglycan synthesis and helping to stabilize and protect proteoglycans.