There are many natural agents that can be used to improve outcomes for patients with osteoarthritis, but few have more research and years of clinical support than glucosamine, chondroitin, hyaluronic acid, and methylsulfonylmethane (MSM). These agents are components of cartilage and synovial fluid, helping to provide shock absorption to the joint and decrease friction with movement. For example, glucosamine is naturally produced by chondrocytes and is necessary for the manufacture of glycosaminoglycans, a key component of cartilage. Hyaluronic acid is a central component of synovial fluid. Glucosamine sulfate, in particular, has been shown to stimulate the anabolic process of cartilage metabolism and improve clinical outcomes more effectively than glucosamine HCl.
Hydrolyzed collagen is clinically researched to support joint health. Studies show that collagen peptides provide the building blocks necessary to manufacture articular cartilage and that they upregulate chondrocyte activity, increase hyaluronic acid production, and improve microcirculation. Clinical trials have shown that collagen peptides can improve activity-related knee pain in healthy athletes, as well as knee and hip pain during rest and activity in middle-aged people. Vitamin C may enhance these benefits as it is a necessary cofactor in the collagen production process.
Natural anti-inflammatory herbs such as curcuma longa, boswellia serrata, zingiber officinale, devil's claw procumbens, and withania somnifera also play a role in the management of osteoarthritis. Several human clinical trials have confirmed that these herbs have pain-relieving properties and may be beneficial for people with osteoarthritis. Curcuma longa contains active ingredients known as curcuminoids, which have been shown to inhibit NF-kappa B and TNF-alpha in chronic inflammatory conditions. Research trials have shown that curcuminoids can reduce the need for pain medications such as acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) in people with osteoarthritis. They may also decrease post-exercise muscle soreness. In addition to their anti-inflammatory action on NF-kappa B and TNF-alpha, curcuminoids inhibit matrix metalloproteinase-3, an enzyme known to break down cartilage. This means it both improves symptoms and protects joints from further damage. Joint Matrix Liquid specifically uses a proprietary blend of curcuminoids that is standardized to a minimum curcuminoid content of 95% curcumin, BDMC, and DMC. This patented blend of curcuminoids, known as uC3 Clear Complex, has over 80 research articles and over 45 clinical studies to support its effectiveness and safety.
Boswellia's clinical benefits for osteoarthritis come from its boswellic acid content and its ability to inhibit matrix metalloproteinase-3 and 5-lipoxygenase (5-LOX). Standardized boswellia extracts can decrease pain, reduce swelling, and increase range of motion. One trial found boswellia to be as effective as the NSAID valdecoxib in relieving osteoarthritis symptoms.
Cyto-Matrix Joint Matrix Liquid contains a blend of 11 evidence-based nutrients and herbs to reduce symptoms in people with osteoarthritis, protect the joint from further damage, and reduce the need for anti-inflammatory pharmaceutical medications.
Joint Matrix Liquid manages to deliver evidence-based doses and standardized extracts in a single one-tablespoon-a-day dose, enabling superior clinical results and high patient compliance. Simply put, it's rare to find such a comprehensive blend of well-researched joint health nutrients in a single natural health product.
Adults: Take 1 tablespoon (15 ml) daily or as directed by a healthcare professional. Shake before use. Refrigerate after opening.
Ingredients (each 15ml scoop): Hydrolyzed Collagen (Bovine) 1800mg Glucosamine Sulfate 1500mg Methylsulfonylmethane (MSM) 750mg Ginger Extract (Rhizome, Zingiber officinale) 8:1 100mg Ashwagandha Extract (Whole Plant) 5:1 200mg Devil's Claw Extract (Root Tuber, Harpagophytum procumbens) 4:1 500mg C3 Clear (Curcumin, Curcuma longa) 50mg Boswellia Extract (Resin, Boswellia serrata) 10:1 100mg Hyaluronic Acid (Sodium Hyaluronate) 50mg Zinc (Albion Zinc Bis-glycinate Chelate) 15mg Vitamin C (Ascorbic Acid) 30mg Non-GMO Ingredients Medicinal Ingredients: Purified Water, Sorbitol, Glycerin, Xylitol, Natural Green Apple Flavor, DL-Malic Acid, Potassium Sorbate, Xanthan Gum, Monk Fruit Extract, Citrus Extract, Povidone K-30, Licorice Root Extract.