EMIQ Activated Quercetin

Most absorbable form of quercetin Offers 40 times greater absorption than regular quercetin Provides 167 mg of enzymatically modified isoquercitrin (EMIQ), providing 50 mg of quercetin, plus 50 mg of vitamin C per capsule Provides anti-inflammatory, antioxidant, anti-allergy, and cardiovascular benefits Suitable for vegetarians and vegans Quercetin, a dietary flavonol known to be one of the most potent plant-derived antioxidants, has multiple biological actions, with preclinical studies showing anti-inflammatory, antithrombotic, and vasodilatory benefits. The limiting factor in the clinical efficacy of quercetin appears to be its low bioavailability. Enzymatically modified isoquercitrin (EMIQ) is a mixture of quercetin monoglucoside and its alpha-oligoglucosides that has been shown to have significantly higher bioavailability than other available forms. In animals, EMIQ has been shown to produce a 40-fold increase in Cmax (peak plasma concentration) and an 18-fold increase in area under the curve compared to quercetin. In humans, EMIQ supplementation increased plasma concentrations to a significantly greater extent than other forms, including the aglycone and isoquercitrin (Q3G) forms. Randomized, placebo-controlled trials have shown EMIQ to have clinical benefits not seen with less absorbable forms. In a recent crossover trial in volunteers at risk for cardiovascular disease (i.e., those with elevated blood pressure, lipids, glucose, or waist circumference), EMIQ improved endothelial function (as measured by flow-mediated vasodilation), a key risk factor for hypertension, atherosclerosis, and cardiovascular disease. American football players taking whey protein supplements experienced greater increases in lower limb muscle mass and antioxidant protection when they consumed 42 mg of EMIQ per day compared to whey alone. Two trials found that EMIQ reduced medication use and ocular symptoms of hay fever due to Japanese cedar pollinosis.