The microbial ecosystem of the gastrointestinal (GI) tract has become a "virtual organ system," whose importance in maintaining health and preventing disease is increasingly recognized. The GI microbiota plays a critical role in maintaining innate and cell-mediated immune system homeostasis and improves intestinal barrier function through several mechanisms, including toxin metabolism, tight junction protein phosphorylation, and inflammation reduction. Research has clearly demonstrated the importance of gut bacteria not only in maintaining optimal gastrointestinal health, but also in chronic and systemic diseases such as type 2 diabetes, obesity, and other inflammatory or autoimmune diseases.
Probiotics have multifactorial benefits, modulating gut immune responses and intestinal barrier functions in a strain- and dose-dependent manner. Furthermore, probiotic blends appear to be more effective than individual strains, perhaps due to synergistic activity or because individuals respond differently to different strains.
Probiotic-Pro12 contains 12 bacterial species, each chosen for its ability to withstand stomach acid and high bile concentrations, as well as for its clinically proven benefits through individual mechanisms of action. High-quality lactic acid bacteria require considerable care at all times, which is why more than 20 rigorous quality control measures are implemented to ensure strain consistency and product quality.
Adults: 1 to 3 capsules daily on a full stomach or as directed by a healthcare practitioner. Take at least 2 to 3 hours before or after taking antibiotics.
Medicinal Ingredients per Capsule: Total Bacterial Culture 12 billion CFU: Lactobacillus casei (HA-108) (whole cell) (human) 25% 3.00 billion cfu Lactobacillus rhamnosus (HA-111) (whole cell) (human) 12% 1.44 billion cfu Bifidobacterium breve (HA-129) (whole cell) (human) 10% 1.20 billion cfu Bifidobacterium longum subsp. longum (HA-135) (whole cell) (human) 10% 1.20 billion cfu Lactobacillus acidophilus (HA-122) (whole cell) (human) 10% 1.20 billion cfu Lactobacillus plantarum (HA-119) (whole cell) (plant) 10% 1.20 billion cfu Lactobacillus rhamnosus (HA-114) (whole cell) (human) 10% 1.20 billion cfu Bifidobacterium bifidum (HA-132) (whole cell) (human) 5% 0.60 billion cfu Lactobacillus fermentum (HA-179) (whole cell) (dairy) 5% 0.60 billion cfu Lactobacillus salivarius (HA-118) (whole cell) (human) 1% 0.12 billion cfu Lactobacillus paracasei (HA-196) (whole cell) (dairy) 1% 0.12 billion cfu Bifidobacterium animalis subsp. lactis (HA-194) (whole cell) (dairy) 1% 0.12 billion CFU CFU: Colony Forming Units*. Guaranteed minimum of 12 billion active cells per capsule at the expiration date. Guaranteed minimum of 18 billion active cells per capsule at the manufacturing date. Nonmedicinal ingredients: Maltodextrin, vegetarian capsule (carbohydrate gum [cellulose], purified water), fructooligosaccharides (natural fructose complex molecules derived from beets), inulin (chicory), vegetable-grade magnesium stearate (lubricant), silica, ascorbic acid.
