{"title":"SAM-e","description":"","products":[{"product_id":"same-tmg-citron","title":"Same + TMG Lemon","description":"\nHelps relieve the symptoms and pain of osteoarthritis.\nHelps support healthy liver function.\u003cbr\u003e\n\n\n\nS-adenosyl-L-methionine (SAMe) is a natural substance formed in the body from the amino acid methionine and the \"energy molecule\" adenosine triphosphate (ATP). The formation of SAMe is catalyzed by methionine adenosyltransferase and depends on cofactors such as vitamin B6, vitamin B12, folate, and magnesium. SAMe has been studied as a supportive nutrient for liver health, joint comfort, metabolic reactions, and a healthy mood.\n","brand":"Xymogen","offers":[{"title":"30 Packs","offer_id":41636905746603,"sku":"same-tmg-citron-30-paquets","price":133.99,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2993\/1664\/files\/same-tmg-xymogen.png?v=1777921066"},{"product_id":"same-400-aor","title":"SAMe 400","description":"\nPromotes Mood Balance\nImproves Mood and Emotional Well-being\nRelieves Symptoms of Osteoarthritis\nProvides an Effective Dose and Stable Form of SAMe\nPromotes Methylation\n\n\nS-adenosyl-L-methionine (SAMe) is a naturally occurring compound and methyl group donor that supports the methylation cycle, a metabolic process essential for many aspects of health. Methylation is essential for ridding the body of certain toxins, as well as for certain individuals, such as those with chronic liver disorders, who cannot produce adequate levels of SAMe.\nSAMe's effectiveness in supporting a balanced mood has been demonstrated in numerous clinical studies. SAMe is so effective at boosting depression that it is legally registered as a prescription medication in several European countries for mood balancing. One study has also demonstrated the effectiveness of SAMe when taken as a common prescription medication for mood. SAMe is believed to work by boosting serotonin, dopamine, and melatonin levels in the brain, where low levels of these substances are commonly associated with mood imbalances such as anxiety and depression. SAMe has also been found to promote joint health in osteoarthritis patients as effectively as a well-known anti-inflammatory drug, reducing inflammation and protecting joint tissue from degradation.\nAOR's SAMe 400 provides an effective dose and stable form of this valuable compound in an enteric-coated tablet for maximum effectiveness. The first SAMe supplement was introduced by AOR in Canada in 2000.\n","brand":"AOR","offers":[{"title":"30 Tablets","offer_id":41613049888939,"sku":"same-400-aor-30-comprimés","price":80.99,"currency_code":"CAD","in_stock":true},{"title":"60 Tablets","offer_id":41613049921707,"sku":"same-400-aor-60-comprimés","price":134.99,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2993\/1664\/products\/image_a71b4c3a-e0a0-4b72-84db-25080701428e.png?v=1749236308"},{"product_id":"same-s-adenosylmethionine-pure-encapsulations","title":"SAMe (S-Adenosylmethionine)","description":"\nSAMe with enhanced stability to promote healthy mood balance and comfort for osteoarthritic joints\n\n\nSAMe (S-Adenosylmethionine) is a metabolite found in all living cells. It is a methyl group donor in over 100 different reactions and contributes to the synthesis, activation, and\/or metabolism of hormones, neurotransmitters, nucleic acids, phospholipids, and proteins. Methyl groups act as a signal in the body, regulating gene expression and cellular function. As demonstrated in over 40 clinical studies, SAMe also promotes mood balance. In a meta-analysis pooling results from 25 controlled clinical trials involving 791 subjects, SAMe had a statistically significant positive effect on mood, likely due to its support for the synthesis and activity of monoamine (a neurotransmitter), including dopamine and serotonin. It also promotes healthy protein turnover and maintains healthy phospholipid methylation to support phosphatidylcholine production and the integrity and fluidity of cell membranes. Studies suggest that it also supports joint comfort and flexibility in people with osteoarthritis. In a meta-analysis pooling results from 11 studies, SAMe demonstrated statistically significant support for joint function. It is believed to relieve osteoarthritis pain by supporting proteoglycan synthesis and helping to stabilize and protect proteoglycans.\n","brand":"Pure Encapsulations","offers":[{"title":"60 Capsules","offer_id":41631153062059,"sku":"same-s-adenosylmethionine-pure-encapsulations-60-capsules","price":75.99,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2993\/1664\/products\/sam6c.png?v=1749236033"},{"product_id":"same-200-mg","title":"SAMe · 200 mg","description":"Relieves osteoarthritis pain\nKey factor in several biological pathways, including methylation reactions, glutathione formation, and glutathione S-transferase activity\nThe enteric coating protects SAMe from degradation by stomach acid, allowing for significantly improved intestinal absorption.\n200 mg of SAMe per tablet for flexible dose titration\nSAMe is produced through a natural fermentation process that yields higher potency than synthetic alternatives.\nSuitable for vegetarians\n\nS-Adenosyl-L-Methionine (SAMe) has several essential physiological functions and is the connecting link between three key metabolic pathways. It is well recognized as a unique methyl donor for over 100 biological reactions, including DNA methylation. It also links methylation to the synthesis of polyamines (necessary for cell survival and growth) and transsulfuration, which is responsible for the production of cysteine, the rate-limiting factor in glutathione synthesis. Its unique positioning within these intersecting pathways explains its role as a regulator of redox status, cellular metabolism, proliferation, and apoptosis.\u003cbr\u003e\u003cbr\u003e It has been clinically proven to alleviate a number of conditions, including osteoarthritis, fibromyalgia, neurodegenerative diseases, depression, and liver disease. For patients with major depressive disorder, SAMe has been shown to be effective not only compared to standard antidepressants, but also in non-responders to selective serotonin reuptake inhibitors (SSRIs). It has also been shown to reduce the incidence of sexual dysfunction that commonly accompanies SSRI\/SNRI treatment. SAMe has also shown comparable efficacy for osteoarthritis to NSAIDs, including celecoxib. More importantly, this is likely due to increased cartilage formation, glutathione production, DNA methylation, and gene expression that contribute to its effectiveness—a stark contrast to pharmaceutical pain relievers. Research also suggests benefits for neurodegenerative diseases and potentially for improving endothelial function.","brand":"Bioclinic Naturals","offers":[{"title":"30 Tablets","offer_id":43152808837291,"sku":"same-bioclinic-naturals-30c","price":31.99,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/2993\/1664\/products\/t78uhkkxptxkzns3vpqv_7c07bfaf-3c4f-4ff5-86cb-6f04b051541f.jpg?v=1749234645"}],"url":"https:\/\/www.unytii.com\/en\/collections\/sam-e.oembed","provider":"Unytii - Suppléments et Produits Naturels","version":"1.0","type":"link"}